About me

I am a go-getter with big dreams and an even bigger to-do list! 💡

Whether it’s diving into the world of bioinformatics, leading a team to success, or helping others navigate complex challenges, I do it all with passion.

By day, I’m crunching data and solving real-world problems with code and creativity.

By night? You’ll find me curled up with a book, brainstorming my next big idea.

But my curiosity doesn’t stop there, I am fascinated by space and the Red Planet! Mars may be millions of miles away, but studying it keeps my imagination fueled and my scientific brain buzzing.

I don’t just work — I lead

I don’t just help — I empower

And I don’t just dream — I do

The goal? To build, innovate, break barriers, and solve as many problems as possible

If you are looking for someone who can decode complex biological data, optimize workflows, and drive tech-forward solutions, let's connect and create something extraordinary!

What i'm doing

  • Bioinformatics & Cancer Research

    Bioinformatics & Cancer Research

    Harnessing the power of computational biology to decode cancer, analyze omics data, and push the boundaries of precision medicine.

  • Space Exploration

    Space Exploration

    Exploring the unknown and leveraging bioinformatics to understand space biology and its futuristic possibilities.

  • Tech & Innovation

    Tech & Innovation

    Finding solutions at the intersection of Biology and Technology to tackle real-world challenges.

  • Leadership & Impact

    Leadership & Impact

    Leading and making a difference in research, tech and helping others navigate their own paths to success.

Isha Parikh
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Skills

Resume

Education

  1. Northeastern University

    Master of Science in Bioinformatics

    2022 — 2024

  2. D. Y. Patil University

    Bachelor of Technology in Biotechnology

    2016 — 2020

Experience

  1. Bioinformatician

    Dana Farber Cancer Institute

    Feb, 2024 — Present   •

    Boston, MA

    • Led the analysis of scRNA-seq and pseudo bulk data from 50+ relapsed & refractory multiple myeloma patients, identifying genetic variations and preferential dependencies in CAR-T therapeutic resistance
    • Initiated performance benchmarking of alignment (STAR Solo, 2-pass), mutation profiling (GATK - Mutect2 on Terra cloud, FreeBayes, Souporcell), and copy number analysis (Scevan, Vartrix) to identify faster tools for efficient project execution
    • Collaborated with bench scientists to integrate sample processing with computational analysis ensuring seamless workflow execution & streamlined data integration across multiple sequencing technologies (CEL-Seq2, MARS-seq, CITE-seq, 10x Genomics V2) for Loupe Browser reducing data visualization time by 60% for high-dimensional NGS datasets
    • Optimized Nextflow RNAvar pipeline which enhanced scalability and reduced analysis time for variant calling workflow & applied advanced statistical tools using Seurat, LIMMA, DESeq2 & FGSEA on HPC to identify key biological processes
    • Designed and deployed an R Shiny app automating data preprocessing and real-time visualization(UMAP & Heatmaps) that enabled 10+ bench scientists to study genes of interest on high throughput single cell datasets

  2. Data Analyst

    Vasta Bioinformatics Pvt. Ltd.

    Apr, 2021 — Aug, 2022   •

    Mumbai, India

    • Managed 500+ patient records in neural cancer ensuring data integrity & compliance with SOP
    • Partnered with audit team to manage data on EMR (CASIS, EPIC, ORCA, MINDscape) boosting data retrieval efficiency by 30%
    • Engaged with clients to align data requirements with SOPs & trained colleagues for workflow efficiency, data quality & compliance
    • Maximized data quality to over 99% with data abstraction protocols ensuring the validity & reproducibility for preclinical study

  3. Intern

    National Collateral Management Services Limited

    May, 2019 — May, 2019   •

    Navi Mumbai, India

    • Analysed different food samples in the analytical lab and microbiology lab
    • Performed quality anaylsis techniques using Soxhlet, Kjeldahl along with the manual methods
    • Examined quality and quantity of proteins, fats, carbohydrates, moisture, metals, microbes present in food samples

  4. Trainee

    Central Dogma Pvt. Ltd.

    May, 2018 — May, 2018   •

    Pune, India

    • Isolated plasmid DNA vectors, performed gene amplification using PCR, designed primers, and digested vectors and PCR products with specific restriction enzymes for cloning
    • Conducted agarose gel electrophoresis for DNA analysis, purified digested vectors and PCR products using gel extraction kits, and confirmed recombinants through colony PCR
    • Prepared competent Dh5 alpha cells, transformed ligation mixtures using heat shock treatment, cultured transformants on selective media, and validated recombinants through colony PCR and agarose gel electrophoresis
    • Estimated proteins, carbohydrates, triglycerides, vitamin C, cholesterol, sugar and flavonoids in samples
    • Detected microbes and coliform in food samples

Portfolio